Health Monographs

Orotates and the Mineral Transporters of Dr. Nieper

What’s the best way to take mineral supplements? Picolinates? Amino acid chelates? Chelates involving other organic acids such as citrates? Whenever anyone asks my opinion on such matters, I find myself giving an answer they often don’t expect: “Try orotates!” The blank looks I usually get in response tell me that most people need some educating on the subject, hence this article. read more...

BHT and the silent epidemic...Herpes

BHT has been shown to lower the incidence of herpes outbreaks, and to shorten the duration of those outbreaks that do occur. It appears to work better in some people than in others — perhaps because the susceptibility of human cells to membrane-altered viruses varies from person to person. For some people BHT may be an excellent prevention; for others it may ineffective. There’s no way to predict in advance whether it will work for you — you simply have to try it to find out. read more...

How orotates work - The biochemistry of ‘vitamin B13’

This article addresses two biochemical puzzles about the mineral orotates: how they get into cells and what they do once they’re in.

We begin with the fact that the orotate salts are electrically neutral and relatively stable against dissociation, properties that seem to be crucial for the ability of orotates to participate in intracellular mineral uptake and transport. Dissociation is the process that takes place when a salt is dissolved in a solvent such as water and breaks up into its component ions. Table salt dissolved in water, for example, dissociates into sodium and chloride ions. At physiological pH the orotate salts are much more stable than table salt and will not readily dissociate into free orotic acid plus a mineral ion.


Will diabetes research lead to a cure for aging?

The body’s aging process might seem, at first glance, to be unrelated to the disease we call ‘diabetes’. After all, the root causes of diabetes have to do with how the hormone ‘insulin’ is produced or used in the body, whereas the root causes of aging appear to be free radicals, malfunctioning genes, and damaged proteins.

Nevertheless, there is a connection between diabetes and aging — if not in their ultimate causes, then at least in the biochemical disruptions resulting from these causes, and in the symptoms that are produced by them. Because of these similarities, both diabetes and aging respond to some of the same treatments. This means that diabetes research is giving rise to anti-aging techniques, even though not a great deal of effort is going directly into anti-aging research itself. And it means that some of the supplements that are normally targeted at diabetic complications should also be used to fight aging in non-diabetics.

CardioPeptase, The “Miracle” Microbial Enzyme

Heard about CardioPeptase, the proteolytic enzyme sometimes known as serrapeptase or serratiopeptidase? Chances are you haven’t, until now. It’s only been available as a nutritional supplement in the US for the past few years. Yet for over 30 years serrapeptase has been gaining wide acceptance in Europe and Asia as a potent analgesic and anti-inflammatory drug. It’s been used to promote wound healing and surgical recovery. Recent Japanese patents even suggest that oral serrapeptase may help treat or prevent such viral diseases as AIDS and hepatitis B and C. But perhaps its most spectacular application is in reversing cardiovascular disease. In fact, serrapeptase appears so effective in unblocking carotid arteries that one researcher—Dr. Hans Nieper, the late, eminent internist from Hannover, Germany—called it a “miracle” enzyme. read more...

Selenium Supplements—Why Selenate Rates (and Selenite Bites)

Since selenium (Se) was first identified as an essential trace mineral by Schwarz and Foltz in 1957, researchers have discovered that getting enough selenium in the diet just might protect against cardiovascular disease, viral infections including influenza and HIV, rheumatoid arthritis, liver disease, and some forms of cancer as well.

Selenium is now recognized as essential for a variety of bodily functions, of which perhaps the most important and certainly the best known is antioxidant defense. Selenium-binding enzymes known as glutathione peroxidases are responsible for mopping up such harmful oxidants as hydrogen peroxide and lipid peroxides. Other selenoproteins—proteins which store, carry, or utilize Se—are involved in thyroid hormone metabolism, muscle function, male fertility, and immune regulation.

CDP-Choline and alpha GPC: What to Feed Your Head

Aging humans and animals tend to suffer from impaired short-term memory. This loss of working memory is largely the result of deficient functioning of the “cholinergic” neurons in a part of the brain known as the basal forebrain. (Cholinergic neurons are the brain cells involved in acetylcholine synthesis, signaling, and metabolism.) The age-related deficits in this part of the brain include decreased synthesis and release of acetylcholine, as well as decreases in the number of cholinergic brain cells and in the number and function of acetylcholine receptors on such cells.


Red Yeast Rice—Cholesterol-Busting SuperFood or Just Another Pharmaceutical?

When is a natural food product not a natural food product? Whenever the FDA says so, judging by the results of a recent court case.

Red yeast rice is an all-natural whole food powder made from dried fermented rice, with a remarkable ability to lower LDL-cholesterol levels with minimal side effects. In a double-blind, placebo-controlled study at UCLA, a dose of 2.4 grams of red yeast rice powder per day decreased LDL-cholesterol by 18% after 8 weeks. Similar studies conducted in China with a more concentrated form of the same product resulted in decreases in LDL-cholesterol of up to 32% after 8 weeks. Pretty impressive results for a nutraceutical, you’d have to agree.


The genistein rush: Researchers rush to discover the medicinal properties of soy-derived substances

A simple search of the medical research literature, using the search-word ‘genistein’, turns up more than 5500 research articles, most of them published in just the past several years. What is the reason for this surge of interest in a substance that, in the 1950s, was believed to be nothing more than a potential anti-fertility agent?

Genistein is an isoflavone extracted from soybeans. It is just one of several isoflavones found in soy and related plants. Daidzein and glycitein are two more, which share some of genistein’s physiological properties as well as having unique properties of their own. In the body, genistein inhibits various enzymes that have wide-ranging actions in many tissues. This means that its physiological effects are diverse and could impact many different ailments. The half-life of genistein supplements in the body is about 8 hours.


Ferulic Acid: an intriguing new supplement with some unusual antioxidant properties

Ferulic acid (FA) is a substance found in the seeds and leaves of most plants, especially in the brans of grasses such as wheat, rice, and oats. Its chemical structure strongly resembles that of curcumin, the substance responsible for the yellow color of the spice turmeric.

The amount of ferulic acid in plant materials varies widely depending on the species and growing conditions; supplements are therefore a more reliable source of this substance than food or unprocessed herbal materials.

Ferulic acid has antioxidant properties that make it an important anti-aging supplement, and they also contribute to FA’s other potential uses. These include applications in diabetes, cardiovascular disease, cancer, neuroprotection, bone degeneration, menopause, immunity, and (perhaps) athletic performance. Let us look at these uses in more detail.

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